Col1a1-IRES-CreERT2
品系全名
C57BL/6Smoc-Col1a1em(IRES-CreERT2)1Smoc
目录号
NM-KI-225031
品系状态
活体
基因信息
基因名
Col1a1
品系描述
验证数据
Fig1. Cre mediated recombination in femur of Col1a1CreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Col1a1CreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: lung, stomach, teeth, pancreas, small intestine, colon, spleen, epididymis, skin, pituitary gland and skull. A few cells expressed in brain, eyeball, heart, liver, salivary gland, adrenal gland, kidney, muscle, thymus. Tissues that unexpressed include spinal cord, brown fat.The control group is expressed before induction. (39-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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