B2m-KO(M-NSG)
品系全名
NOD.Cg-PrkdcscidIl2rgem1B2mem1Smoc
目录号
NM-NSG-002
品系状态
活体
基因信息
基因名
B2M
品系描述
敲除B2m基因exon 2-3区域，获得M-NSG背景B2m基因敲除小鼠模型，是异种移植物移植研究的理想模型，也可用于为移植研究提供无胰岛炎、无MHC I类胰岛组织。
应用领域：免疫缺陷，免疫系统，移植研究
*使用本品系发表的文献需注明: B2m-KO(M-NSG) mice (Cat. NO. NM-NSG-002) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Detection of MHCII and B2m expression in spleen in B2m-KO(M-NSG) mice by RT-PCR.
Abbr. M, DNA marker.
Fig2. Expression characterization of mouse MHC I and MHC II in bone marrow, blood, spleen in B2m-KO(M-NSG) mice.
Fig 3. Body weight growth curve of huPBMC-B2m-KO(M-NSG) mice.
Fig 4. Survival rate of huPBMC-B2m-KO(M-NSG) mice.
Fig 5. GvHD scores of huPBMC-B2m-KO(M-NSG) mice.
Fig 6. Percentage of hCD45-positive cells of huPBMC-B2m-KO(M-NSG) mice.
Fig 7. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-B2m-KO(M-NSG) mice.
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