hPSGL-1

品系全名

C57BL/6Smoc-Selplgem1(hSELPLG)Smoc

目录号

NM-HU-00046

品系状态

胚胎冻存

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基因信息

基因名
Selplg

基因曾用名

CD162; Psgl1; Selp1; Selpl; Psgl-1

NCBI ID

20345

MGI ID

106689

Ensembl ID

ENSMUSG00000048163

Pubmed

Selplg

人类同源基因

SELPLG

品系描述

通过同源重组，将小鼠Selplg基因进行人源化修饰。
应用领域：免疫治疗；肿瘤研究；药物筛选

验证数据

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Fig1. Detection of SELPLG expression in spleen by RT-PCR.Wild type：only one band at 539bp with primers F1/R1(mSelplg);Homozygous: only one band at 320bp with primers F2/R2(mSELPLG); Abbr：M,100bp Plus DNA ladder；HO, homozygous; HE, heterozygous; WT, wild type

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Fig2. Detection of hPSGL-1 expression on B cells in blood in hPSGL-1 knockin mice. 

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Fig3. Detection of hPSGL-1 expression on Monocytes and Granulocytes in blood in hPSGL-1 knockin mice. 

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Fig4. Detection of hPSGL-1 expression on B cells in bone morrow in hPSGL-1 knockin mice.

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Fig5. Detection of hPSGL-1 expression on Monocytes and Granulocytes in bone morrow in hPSGL-1 knockin mice.

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Fig6. Detection of hPSGL-1 expression on T cells in bone morrow in hPSGL-1 knockin mice.

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Fig7. Detection of hPSGL-1 expression on NKs and DCs in bone morrow in hPSGL-1 KI mice.

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Fig8. Detection of hPSGL-1 expression on B cells in spleen in hPSGL-1 knockin mice.

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Fig9. Detection of hPSGL-1 expression on Monocytes and Granulocytes in spleen in hPSGL-1 knockin mice.

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Fig10. Detection of hPSGL-1 expression on T cells in thymus in hPSGL-1 knockin mice.

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