hFCRN(2)

Fig1. Validation of hFCGRT and mFCGRT expression in humanized Fcgrt mice by Western blot. These results showed that hFCGRT can be expressed in the liver and kidney of humanized Fcgrt homozygous and heterozygous mice，while mFCGRT can not be expressed in the humanized Fcgrt homozygous mice.

Fig2. Blood concentration curves of Keytruda in C57BL/6 and hFcRn KI mice. (n=3/time point/group)

Fig3. Blood concentration curves of Cyramza(A) and Keytruda(B) in C57BL/6, hFcRn KI and Fcgrt-KO mice.(n=3/time point/group)

Fig4. In vivo PK profiles of TAA scfv-anti HSA VHH in hALB/hFCRN mice(NM-HU-200278) (female, 10-12weeks, n=3 mice/timepoint), which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003). (In cooperation with the third party).

Fig5. Blood concentration curves of test articles in C57BL/6 and hFcRn/hALB dKI mice(NM-HU-200278) , which were generated by crossing hFCRN(NM-HU-190070) with hALB(NM-HU-200003).(In cooperation with the third party)