hALB/hFCRN

品系全名

C57BL/6Smoc-Albem3(hALB)Fcgrtem2(hFCGRT)/Smoc

目录号

NM-HU-200278

品系状态

活体

导出PDF

基因信息

基因名
ALB

基因名
Fcgrt

品系描述

通过hALB(NM-HU-200003)与hFCRN(NM-HU-190070)小鼠交配获得
应用领域:肿瘤研究;免疫治疗;药物筛选

验证数据

image.png

Fig.1 Detection of hALB (A) and mALB (B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.image.png

Fig.2 Expression characterization of hFCRN in hALB/hFCRN dKI mice by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)  

image.png

Fig.3 In vivo PK profiles of TAA scfv-anti HSA VHH in hALB/hFCRN mice (female, 10-12weeks, n=3 mice/timepoint).

(In cooperation with the third party).

image.png

Fig.4 Blood concentration curves of test articles in C57BL/6 and hFcRn/hALB dKI mice. (In cooperation with the third party) 

image.png

Table 1 Noncompartmental Analysis (NAC) results of test articles in hFcRn/hALB dKI mice. (In cooperation with the third party) 

image.png

Fig.5 Fitting curves of blood concentration in C57BL/6 and hFcRn/hALB dKI mice. (In cooperation with the third party) 


你也可能感兴趣

Tamoxifen诱导Cre-ERT2小鼠 使用指南

Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。

查看
【小鼠大学问】基因工程小鼠的命名规则

常见的基因工程小鼠可以分为两种命名方式,包括基因定点修饰的小鼠命名,比如:敲除、敲入、点突变等等,和随机转基因的小鼠命名。

查看