Th-IRES-CreERT2
品系全名
C57BL/6Smoc-Them1(IRES-creER)Smoc
目录号
NM-KI-200082
品系状态
活体
基因信息
基因名
Th
品系描述
验证数据
Fig1. Cre mediated recombination in brain of ThCreERT2/+;Rosa26tdTomato/+ mouse. (VTA: ventral tegmental area)
Fig2. Detection of tdTomato(red) in various tissues of ThCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: brain, islet. A few cells expressed in spinal cord, pituitary gland, small intestine, colon, skin, thymus and adrenal gland. Tissues that unexpressed include eye, heart, lung, liver, stomach, salivary glands, brown fat, kidney, spleen, muscle. Tamoxifen induction began at 49 days of age, with testing at 58 days. (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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