Cd8a-2A-CreERT2
品系全名
C57BL/6Smoc-Cd8aem1(2A-CreERT2)Smoc
目录号
NM-KI-234690
品系状态
活体
基因信息
基因名
Cd8a
品系描述
鉴定方案
验证数据
Fig1. CreERT2 mediated recombination in thymus of Cd8aCreERT2/+; Rosa26tdTomato/+mouse.
Fig2. Detection of tdTomato(red) in various tissues of Cd8aCreERT2/+; Rosa26tdTomato/+ mouse. Expression tissues include: lungs, liver, stomach, large intestine, small intestine, spleen, adrenal glands, reproductive organs, muscles, thymus. Scattered cells were expressed in adrenal gland, spleen, muscle. Tissues that unexpressed include brain, spinal cord, eyes, heart, salivary glands, brown adipose tissue, kidneys, pancreas, skin, pituitary gland. (59-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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