Syn1-IRES-CreERT2
品系全名
C57BL/6Smoc-Syn1em1(IRES-CreERT2)Smoc
目录号
NM-KI-231789
品系状态
精子冻存
基因信息
基因名
Syn1
品系描述
验证数据
Fig 1. Cre-mediated recombination in brain of Syn1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Cre-mediated recombination in brain of Syn1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 3. Detection of tdTomato (red) in various tissues of Syn1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: brain, retina, islet, pituitary. A few cells expressed in spinal cord, heart, lung, liver, adrenal gland, kidney, small intestine, colon, muscle and thymus. Tissues that unexpressed include stomach, salivary glands, brown fat, spleen, uterus, skin. Tamoxifen induction began at 35 days of age, with testing at 45 days. (45-day old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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