Mrc1-2A-CreERT2
品系全名
C57BL/6Smoc-Mrc1em(2A-CreERT2)Smoc
目录号
NM-KI-220031
品系状态
活体
基因信息
基因名
Mrc1
品系描述
验证数据
Fig 1. Cre-mediated recombination in liver of Mrc1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) in various tissues of Mrc1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: liver. A few cells expressed in large intestine, spleen, skin, thymus. Tissues that unexpressed include brain, spinal cord, retina, heart, lung, stomach, salivary glands, brown fat, pituitary gland, kidney, pancreas, small intestine, testis, muscle, adrenal gland. (4.5-month old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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