hIL12A
品系全名
C57BL/6Smoc-Il12atm3(hIL12A)/Smoc
目录号
NM-HU-2000056
品系状态
胚胎冻存
基因信息
基因名
Il12a
品系描述
通过同源重组，将小鼠Il12a基因进行人源化修饰。
应用领域：细胞因子人源化模型；药物筛选
*使用本品系发表的文献需注明: hIL12A mice (Cat. NO. NM-HU-2000056) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Detection of IL12A expression in spleen by RT-PCR.
Wild type: only one band at 198 bp with primers F1/R1(mIl12a);
Homozygous: only one band at 488 bp with primers F2/R2(hIL12A);
Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of human IL12P70 and mouse IL12P70 expression in serum by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. hIL12A/hIL12B and C57BL/6 mice were i.p. injected with LPS for 2h.
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