hIL21R
品系全名
C57BL/6Smoc-Il21rtm1(hIL21R)Smoc
目录号
NM-HU-210031
品系状态
胚胎冻存
基因信息
基因名
IL21R
品系描述
利用ES细胞打靶方式，将小鼠Il21r基因全部或者部分替换为人源IL21R。从而表达人或人鼠嵌合IL21R蛋白，取代小鼠内源Il21r蛋白的表达。
应用领域：免疫治疗；药物筛选
*使用本品系发表的文献需注明: hIL21R mice (Cat. NO. NM-HU-210031) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 Detection of IL21R expression in spleen and thymus by RT-PCR in hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).
Wild type: only one band at 189 bp with primers F1/R1(mIl21r);
Homozygous: only one band at 177 bp with primers F2/R2(hIL21R).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of hIL21R expression in activated splenocyte in WT C57BL/6 and HO hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).
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