hMERTK

品系全名

C57BL/6Smoc-Mertkem1(hMERTK)/Smoc

目录号

NM-HU-2000031

品系状态

胚胎冻存

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基因信息

基因名
Mertk

基因曾用名

Eyk; Mer; Nyk; nmf12

NCBI ID

17289

MGI ID

96965

Ensembl ID

ENSMUSG00000014361

Pubmed

Mertk

人类同源基因

MERTK

品系描述

通过同源重组，将小鼠Mertk基因进行人源化修饰。
应用领域：免疫治疗；药物筛选

验证数据

image.png

Fig1. Detection of MERTK expression by RT-PCR. 

Wild type: only one band at 201 bp with primers F2/R2(mMertk);

Homozygous: only one band at 122 bp with primers F1/R1(hMERTK); 

Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

hMERTK-1.png

Fig2. Human MERTK expression on lymph nodes is confirmed by Western Blot in the humanized MERTK mice. 

Human MERTK expresses on lymph nodes in the humanized MERTK mice.image.png

Fig3. Detection of hMerTK expression on human PBMC.

image.png

Fig4. Detection of hMerTK expression on BMDM and BMDC in hMerTK KI mice. 

Abbr. BMDM, Bone Marrow Derived Macrophage; BMDC, Bone Marrow Derived Dendritic cell.

hMERTK-2.png

Fig5. Human MERTK expression on spleen cells is confirmed by immunofluorescence in the humanized MERTK mice. 

Human MERTK expresses obviously on spleen cells in the humanized MERTK mice.

hMERTK-3.png

Fig6. Human MERTK expression on thymus is confirmed by immunofluorescence in the humanized MERTK mice. 

Human MERTK expresses obviously on thymus in the humanized MERTK mice.

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