hCCR8(BALB/c)(2)

品系全名

BALB/cAnSmoc-Ccr8em(hCCR8)Smoc

目录号

NM-HU-220501

品系状态

胚胎冻存

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基因信息

基因名
CCR8

品系描述

利用同源重组,将小鼠Ccr8 基因进行人源化修饰。

验证数据

image.png

Fig1. Detection of hCCR8 expression on spleen-derived activated T cells and Tregs in hCCR8 KI mice.

*Splenocytes were activated by anti-mCD3/CD28 antibody in vivo.image.png

Fig2. In vivo antitumor responses of anti-hCCR8 alone in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor. 

(A) Mean tumor growth curves upon treatment; (B) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor; (C) Expression of hCCR8 in spleen in hCCR8 (v2) mice bearing CT26 tumor.image.png

Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-CTLA-4 in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor. 

(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment; (C) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor.


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