Tg-2A-CreERT2
品系全名
C57BL/6Smoc-Tgem1(2A-CreERT2-WPRE-polyA)Smoc
目录号
NM-KI-215040
品系状态
精子冻存
基因信息
基因名
Col1a2
品系描述
验证数据
Fig1. Cre mediated recombination in thyroid of TgCreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of TgCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: thyroid gland and salivary gland. A few cells expressed in lung, liver, adrenal gland, kidney, colon, small intestine, spleen, ovary, thymus and pituitary gland. Tissues that unexpressed include brain, spinal cord, retina, heart, stomach, brown fat, pancreas, muscle, epidermis.Thyroid is expressed before induction.(4-weeks old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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