hFCRN/hALB(SD)

Fig.1 Detection of ALB expression in serum by blood biochemical analysis (n=4). 

Abbr. HO, homozygous; WT, wild type.

Fig.2 Detection of hALB (A) and rALB (B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

Fig.3 Expression characterization of hFCRN in hALB/hFCRN dKI rat by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)   

Fig.4  Blood concentration curve of test articles in hFcRn/hALB dKI rats. 

In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party) 

Fig.5 PK study of Keytruda in  hALB/hFCRN dKl rat. (n=3/time point/group)  

Fig.6 PK study of Cyramza in hALB/hFCRN dKI rat. (n=3/time point/group)