Gad2-IRES-Cre
品系全名
C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc
目录号
NM-KI-200078
品系状态
活体
基因信息
基因名
Gad2
品系描述
验证数据
Fig. 1 Detection of tdTomato (red) in the retina of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in the retinal ganglion cell layer (yellow arrow) and inner nuclear layer (red arrow) of Gad2iCre/+; Rosa26tdTomato/+ mouse.
Fig. 2 Detection of tdTomato (red) in some cells of the cortex and hippocampus drived from Gad2icre/+; Rosa26tdTomato/+ mice.
Fig. 3 Detection of tdTomato (red) in various tissues of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in some cells of the brain, pituitary gland, retina, lung, heart, liver, submandibular gland, brown fat, kidney, pancreas, intestine, colon, epididymis, muscle, skin and thymus can be observed. Tdtomato can not be detected in the spleen and testis. (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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