App-KO

品系全名

C57BL/6Smoc-Appem1Smoc

目录号

NM-KO-190444

品系状态

精子冻存

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基因信息

基因名
App

基因曾用名

Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

染色体位置

16

NCBI ID

11820

MGI ID

88059

Ensembl ID

ENSMUSG00000022892

Pubmed

App

人类同源基因

APP

品系描述

敲除App基因exon 3，建立App基因敲除小鼠模型
应用领域：神经生物学研究，包括神经元分化/迁移、突触调节和阿尔茨海默病相关研究

疾病预测

阿尔茨海默病
Alzheimer's Disease

近似模型的表型

MGI:2174917

参考文献

Dawson GR, Seabrook GR, Zheng H, Smith DW, Graham S, O'Dowd G, Bowery BJ, Boyce S, Trumbauer ME, Chen HY, Van der Ploeg LH, Sirinathsinghji DJ, Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience. 1999 Apr;90(1):1-13

阿尔茨海默病
Alzheimer's Disease

近似模型的表型

MGI:4847595
注：该品系需与Psen1-KO(NM-KO-202110)交配才可能获得预期表型

参考文献

Guo Q, Zheng H, Justice NJ, Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging. 2012 Nov;33(11):2678-91

鞘磷脂沉积病（尼曼-匹克病）
Niemann-Pick Disease

近似模型的表型

MGI:5305067
注：该品系需与Npc1-KO(NM-KO-205053)交配才可能获得预期表型

参考文献

Nunes A, Pressey SN, Cooper JD, Soriano S, Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis. Neurobiol Dis. 2011 Jun;42(3):349-59

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