Col1a1-IRES-EGFP-IRES-MerCreMer

Fig1. Cre mediated recombination in femur of Col1a1^CreERT2/+;Rosa26^tdTomato/+ mouse. 

Fig2. Cre mediated recombination in skull of Col1a1^CreERT2/+;Rosa26^tdTomato/+ mouse. 

Fig3. Detection of EGFP(green) and tdTomato(red) in various tissues of Col1a1^CreERT2/+;Rosa26^tdTomato/+ mouse. The tissues expressing both tdTomato and EGFP include: bone, skull, teeth, eye, lung, stomach, salivary gland, brown adipose tissue, adrenal gland, kidney, small intestine, large intestine, epididymis, and thymus.

The tissues expressing tdTomato include: brain, spinal cord, heart, pancreas, spleen, muscle, skin, and pituitary gland.

In the control group, tdTomato shows minimal leaky expression in: eye, adrenal gland, bone, teeth, epididymis, skin, and thymus.(83-days old, male) (For more detailed information please contact our technical advisor.)