hTP53(2)
品系全名
C57BL/6Smoc-Trp53tm1(hTP53)Smoc
目录号
NM-HU-225052
品系状态
活体
基因信息
基因名
Trp53
品系描述
利用同源重组，将小鼠Trp53基因进行人源化修饰。
*使用本品系发表的文献需注明: hTP53(2) mice (Cat. NO. NM-HU-225052) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 Detection of TP53 expression in thymus by RT-PCR.
Wild type: only one band at 229 bp with primers F1/R1(mTrp53);
Homozygous: only one band at 344 bp with primers F2/R2(hTP53).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of human P53 expression in hTP53(2) knockin mice by WB.
Abbr. M, marker; WT, wild type; HO, Homozygous.
Note. The anti-human P53 antibody cross-reacted with mouse P53 and humanized P53. hTP53(2) and C57BL/6 mice were i.p. injected with LPS.
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