hAPOE4

品系全名

C57BL/6Smoc-Apoetm2(hAPOE4)Smoc

目录号

NM-HU-190002

品系状态

活体

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基因信息

基因名
Apoe

基因曾用名

Apo-E; AI255918

染色体位置

7

NCBI ID

11816

MGI ID

88057

Ensembl ID

ENSMUSG00000002985

Pubmed

Apoe

人类同源基因

APOE

品系描述

通过同源重组，将小鼠Apoe基因进行人源化修饰。
应用领域：心脑血管疾病

验证数据

Apoe4-2.png

Fig1. Genotyping of WT 、KO &  Humanized mice by PCR.

Primer P1/2 Wild type = 342 bp

Primer P3/4 mutant = 332 bp

M：100bp Plus DNA ladder.

image.png

Fig2. Detection of human APOE4 expression in Cerebellum in hAPOE4 knockin mice by IHC. 

Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody. 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig3. Detection of human APOE4 expression in Cornu ammonis 1(CA1) in hAPOE4 knockin mice by IHC. 

Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody. 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig4. Detection of human APOE4 expression in Cornu ammonis 3(CA3) in hAPOE4 knockin mice by IHC. 

Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody. 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig5. Detection of human APOE4 expression in Dentate Gyrus(DG) in hAPOE4 knockin mice by IHC. 

Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody. 

Abbr. HO, homozygous; WT, wild type.

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