hACE2
品系全名
C57BL/6Smoc-Ace2tm3(hACE2-flag-Wpre-pA)Smoc
目录号
NM-HU-200218
品系状态
胚胎冻存
基因信息
基因名
ACE2
品系描述
验证数据
图1. qPCR检测ACE2人源化小鼠各组织中hACE2的表达情况。 结果显示ACE2人源化杂合子和纯合子小鼠中肺、肾、小肠中可以检测到人源ACE2的显著表达；野生型小鼠和杂合子小鼠心、肺、肾、小肠中可以检测到鼠源Ace2的显著表达，纯合子小鼠各组织中均检测不到鼠源Ace2的明显表达。
图2. RT-PCR检测ACE2人源化小鼠肺中ACE2的表达情况。引物对P7/8特异针对446bp的鼠源Ace2序列;引物对P5/6特异针对283bp的人源ACE2序列；M:100bp Plus DNA ladder from Transgen (BM311)。结果表明，纯合子小鼠（HO）肺部只表达人源ACE2，杂合子小鼠（HE）肺部同时表达人源ACE2和鼠源Ace2，野生型小鼠（WT）肺部只表达鼠源Ace2。
发表文献
The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice
来源杂志：International Journal of Molecular Sciences
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