hIL4-Tg(M-NSG)

Fig1. Detection of hIL4 expression by RT-PCR. 

Heterozygous:  one band at 223 bp with primers F1/R1(hIL4); 

Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

Fig 2. Detection of hIL4 expression in serum by ELISA. 

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.、

Fig 3. Body weight growth curve of huPBMC-M-NSG-hIL4 mice. 

Fig 4. Survival rate of huPBMC-M-NSG-hIL4 mice. 

Fig 5. GvHD scores of huPBMC-M-NSG-hIL4 mice. 

Fig 6. Percentage of hCD45-positive cells in peripheral blood of huPBMC-M-NSG-hIL4 mice. 

Fig 7. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-M-NSG-hIL4 model. Human PBMCs (1E7) were injected intravenously into hIL4-Tg(M-NSG) mice (female, 6-8 weeks old, n=10). Blood from mice at different time points after implantation of human PBMCs was taken for flow cytometric analysis.