hTIM3
品系全名
C57BL/6Smoc-Havcr2em1(hHAVCR2)/Smoc
目录号
NM-HU-00054
品系状态
活体
基因信息
基因名
Havcr2
品系描述
通过同源重组，将小鼠Tim3基因进行人源化修饰。
应用领域：免疫治疗；肿瘤研究；药物筛选
*使用本品系发表的文献需注明: hTIM3 mice (Cat. NO. NM-HU-00054) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Detection of TIM3 expression by PCR.
Wild type: only one band at 248 bp with primers F2/R2(mTim3);
Homozygous: only one band at 328 bp with primers F1/R1(hTIM3);
Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Analysis of hTIM3 expression on stimulated CD4+ and CD8+ T cells in hTIM-3 knockin mice by FACS. (Completed in cooperation with CrownBio)
Fig3. Analysis of hTIM3 expression at very low levels on naive T cells by FACS.
Fig4. Analysis of hTIM3 expression at high levels on CD11b+ myeloid cells by FACS.
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