hCD38(2)
品系全名
C57BL/6Smoc-Cd38em2(CD38)Smoc
目录号
NM-HU-190059
品系状态
胚胎冻存
基因信息
基因名
CD38
品系描述
验证数据
Fig1. hCD38 is highly expressed on both B cells and T cells in human PBMC.
Fig2. m/hCD38 is highly expressed on blood and spleen-derived B cells in hCD38 knockin mice.
Fig3. m/hCD38 can be detected on blood-derived T cells in hCD38 knockin mice.
Fig4. m/hCD38 can be detected on spleen-derived T cells in hCD38 knockin mice.
Fig5. In vivo anti-tumor effect of Daratumumab in hCD38 knockin mice. Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab , a drug targeting human CD38, showed a very significant anti-tumor effect , demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.( In cooperation with Crownbio)
Fig6. Binding assay of Daratumumab to hCD38-derived B cells.( In cooperation with Crownbio)
Fig7. Binding assay of Daratumumab to hCD38-derived T cells.( In cooperation with Crownbio)
你也可能感兴趣
Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
查看