Ly6g-2A-CreERT2
品系全名
C57BL/6Smoc-Ly6gem3(2A-CreERT2)Smoc
目录号
NM-KI-200218
品系状态
活体
基因信息
基因名
Ly6g
品系描述
将2A-CreERT2共表达结构插入到小鼠Ly6g基因终止密码子处。
应用领域：Cre工具鼠
*使用本品系发表的文献需注明: Ly6g-2A-CreERT2 mice (Cat. NO. NM-KI-200218) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig1. Cre mediated recombination in spleen of Ly6gCreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Ly6gCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: spleen, colon,lung. A few cells expressed in testis, thymus. Tissues that unexpressed include brain, spinal cord, retina, heart, liver, stomach, salivary glands, brown fat, pituitary gland, kidney, pancreas, small intestine, muscle and epidermis. (8-weeks old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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