R26-CreERT2
品系全名
C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpolyA-CAG-FRT-CreERT2-Rox-WPRE-Rox-polyA)Smoc
目录号
NM-KI-200041
品系状态
活体
基因信息
基因名
Gt(ROSA)26Sor
品系描述
验证数据
Fig1. Detection of tdTomato(red) in various tissues of R26CreERT2/+; Rosa26tdTomato/+ mice by fluorescence assay. Expression tissues include: brain, liver, stomach, thymus, pancreas, colon, heart, kidney and spleen. (For more detailed information please contact our technical advisor.)
Fig2. CreERT2-mediated recombination in peripheral blood of R26CreERT2/+; Rosa26tdTomato/+ mice.
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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