Ucp1-CreERT2
品系全名
C57BL/6Smoc-Ucp1em1(Kozak-CreERT2-WPRE-polyA)Smoc
目录号
NM-KI-190102
品系状态
精子冻存
基因信息
基因名
Ucp1
品系描述
验证数据
Fig1. Cre mediated recombination in brown fat of Ucp1CreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Ucp1CreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: brown fat. A few cells expressed in salivary gland and thymus. Tissues that unexpressed include brain, adrenal gland, retina, heart, lung, liver, stomach, kidney, pancreas, colon, spleen, uterus, muscle, and skin. (9-week old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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