Foxl1-2A-CreERT2
品系全名
C57BL/6Smoc-Foxl1em1(2A-CreERT2)Smoc
目录号
NM-KI-00135
品系状态
活体
基因信息
基因名
Foxl1
品系描述
将2A-CreERT2插入到Foxl1基因的3'端，建立Foxl1-CreERT2他莫昔芬诱导型Cre工具鼠。
*使用本品系发表的文献需注明: Foxl1-2A-CreERT2 mice (Cat. NO. NM-KI-00135) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig 1. CreERT2-mediated recombination in small intestine of Foxl1CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato (red) in various tissues of Foxl1CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: small intestine, colon， stomach,lung, kidney, ovary. A few cells expressed in brain, adrenal gland, muscle, thymus. Tissues that unexpressed include retina, liver, salivary glands, brown fat, pancreas, spleen, skin. (4.5-month old, female) (For more detailed information please contact our technical advisor.)
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Tamoxifen诱导Cre-ERT2小鼠 使用指南
Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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