Vav1-2A-Cre
品系全名
C57BL/6Smoc-Vav1em1(2A-Cre)Smoc
目录号
NM-KI-233228
品系状态
精子冻存
基因信息
基因名
Vav1
品系描述
验证数据
Fig1. Cre mediated recombination in spleen of Vav1Cre/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Vav1Cre/+; Rosa26tdTomato/+ mouse. The tissues of double-positive mice were cryosectioned and directly examined, revealing expression in the following organs: spleen, thymus, lungs, liver, stomach, brown fat, adrenal glands, kidneys, pancreas, small intestine, colon, testicular interstitium, epididymis, muscles and skin. A few cells expressed in brain, retina, heart, salivary glands, spinal cord, pituitary gland. (25-days old, male) (For more detailed information please contact our technical advisor.) !!!!!!!!
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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