Sp7-F2A-CreERT2
品系全名
C57BL/6Smoc-Sp7em1(F2A-CreERT2)Smoc
目录号
NM-KI-232333
品系状态
活体
基因信息
基因名
Sp7
品系描述
将F2A-CreERT2插入到小鼠Sp7基因终止密码子处。
验证数据
Fig1. CreERT2 mediated recombination in bone of Sp7CreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Sp7CreERT2/+; Rosa26tdTomato/+ mouse.
The tissues that express tdTomato include: bone, lung, salivary gland, brown fat, adrenal gland, kidney, spleen, genitalia, muscle, thymus.
Tissues with scattered expression: brain, eyeball, stomach, pancreas.
Tissues with no expression:Spinal cord, heart, large intestine, small intestine, skin, pituitary gland.
(6.5-weeks old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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