Itga2b-2A-CreERT2
品系全名
C57BL/6Smoc-Itga2bem(2A-CreERT2-WPRE-pA)1Smoc
目录号
NM-KI-225072
品系状态
活体
基因信息
基因名
Itga2b
品系描述
验证数据
Fig1. CreERT2 mediated recombination in bone marrow of Itga2bCreERT2/+;Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Itga2bCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: bone marrow, salivary gland, pituitary gland, skin. A few cells expressed in lung, liver, stomach, adrenal gland, kidney, pancreas, small intestine, colon, spleen. Tissues that unexpressed include brain, spinal cord, heart, ovary, muscle, brown fat and thymus. (8-weeks old, female) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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