Dhh-Cre
品系全名
C57BL/6Smoc-Dhhem(Kozak-Cre-WPRE-pA)1Smoc
目录号
NM-KI-225049
品系状态
精子冻存
基因信息
基因名
Dhh
品系描述
验证数据
Fig1. Cre mediated recombination in testis of DhhCre/+;Rosa26tdTomato/+ mouse.
Fig2. Cre mediated recombination in sciatic nerve of DhhCre/+;Rosa26tdTomato/+ mouse.
Fig3. Detection of tdTomato(red) in various tissues of DhhCre/+;Rosa26tdTomato/+ mouse. The tissues of double-positive mice were cryosectioned and directly examined, revealing expression in the following organs: brain, heart, lung, liver, stomach, salivary gland, thymus, sciatic nerve, kidney, pancreas, small intestine, colon, spleen and ovary, skin, adrenal gland and pituitary gland; sporadic cell expression tissues: spinal cord, retina, brown fat, muscle. A few cells expressing it were also identified in the spinal cord, retina, brown fat, and muscle. (4-weeks old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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