Ins2-CreERT2
品系全名
C57BL/6Smoc-Ins2em(CreERT2)1Smoc
目录号
NM-KI-225022
品系状态
精子冻存
基因信息
基因名
Ins2
品系描述
验证数据
Fig 1. CreERT2-mediated recombination in pancreas of Ins2CreERT2/+; Rosa26tdTomato/+ mice.
Fig 2. Detection of tdTomato(red) in various tissues of Ins2CreERT2/+; Rosa26tdTomato/+ mice. Expression tissues include: pancreas, brain(choroid plexus). A few cells expressed in lung, stomach, small intestine, testis, thymus. Tissues that unexpressed include spinal cord, retina, liver, heart, salivary glands, brown fat, adrenal gland, kidneys, colon, spleen, muscle, skin. (7.3-week old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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