Prrx1-2A-CreERT2
品系全名
C57BL/6Smoc-Prrx1em(2A-CreERT2)1Smoc
目录号
NM-KI-225017
品系状态
活体
基因信息
基因名
Prrx1
品系描述
验证数据
Fig1. CreERT2 mediated recombination in skin of Prrx1CreERT2/+; Rosa26tdTomato/+ mouse.
Fig2. Detection of tdTomato(red) in various tissues of Prrx1CreERT2/+; Rosa26tdTomato/+ mouse. Expression tissues include: eye, spinal cord, lung, liver, stomach, salivary glands, brown fat, kidney, pancreas, large intestine, small intestine, spleen, skin, muscle, thymus. Scattered cells were expressed in adrenal glands, genitals. Uninduced group scattered cell expression: brown fat, adrenal gland, thymus, genitalia. (144-days old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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