Lum-2A-CreERT2
品系全名
C57BL/6Smoc-Lumem1(2A-CreERT2)Smoc
目录号
NM-KI-210447
品系状态
活体
基因信息
基因名
Lum
品系描述
验证数据
Fig1. Cre mediated recombination in Cornea of LumCreERT2/+;Rosa26tdTomato/+ mouse. (ep, epithelium; st, stroma.)
Fig2. Cre mediated recombination in skin of LumCreERT2/+;Rosa26tdTomato/+ mouse.
Fig3. Detection of tdTomato(red) in various tissues of LumCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: cornea, skin, stomach, small intestine, colon, spleen and adrenal gland. A few cells expressed in spinal cord, salivary gland, thymus. Tissues that unexpressed include brain, heart, lung, liver, brown fat, pituitary, kidney, pancreas and testis. (9-week old, male) (For more detailed information please contact our technical advisor.)
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Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
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