hTL1A(BALB/c)

品系全名

BALB/cAnSmoc-Tnfsf15em1(hTNFSF15)Smoc

目录号

NM-HU-220602

品系状态

活体

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基因信息

基因名
Tnfsf15

品系描述

利用同源重组,将小鼠Tnfsf15 基因进行人源化修饰。

验证数据

image.png

Fig.1 Detection of TL1A expression in bladder by RT-PCR. 

Wild type: only one band at 285 bp with primers F1/R1 (mTl1a);

Homozygous: only one band at 233 bp with primers F2/R2 (hTL1A).


Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of hTL1A (A) and mTL1A (B) expression in lung homogenate by ELISA (n=3). 

Abbr. HO, homozygous;WT, wild type.

Note. hTL1A and BALB/c mice were i.p. injected with LPS for 6h. The anti-human and mouse TL1A kit cross-reacted with mTL1A and humanized TL1A.

image.png

Fig.3 Detection of TL1A expression on endothelial and epithelial cells in lung in hTL1A mice

Note. The hom hTL1A mice were stimulated with LPS in vivo. 


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