Abcb4-KO(FVB)
品系全名
FVB-Abcb4em1Smoc
目录号
NM-KO-200584
品系状态
活体
基因信息
基因名
Abcb4
品系描述
疾病预测
Cholecystitis
Cholestasis
Intrahepatic Cholestasis
Hepatocellular Carcinoma
Primary Sclerosing Cholangitis
验证数据
Fig1. Serum biochemistry of Abcb4-KO mice (n=3 female and 3 male).
Fig2. Significant bile duct hyperplasia and interstitial focal cell infiltration were observed in the liver of Abcb4-KO mice.
(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by HE staining. (B) Pathological analysis of the liver in Abcb4-KO mice.
Fig3. Collagen fiber hyperplasia were observed in the liver of Abcb4-KO mice.
(A) Liver were collected from FVB wild-type (+/+) and Abcb4-KO mice, and analyzed by Masson staining. (B) Quantification of the Collagen volume fraction (CVF) .
你也可能感兴趣
Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似物)与ERT结合,可使Cre-ERT2进核发挥Cre重组酶活性。
查看