NOD SCID

该品系为非肥胖糖尿病（NOD）小鼠背景携带Scid自发突变。NOD-Scid小鼠不会发生糖尿病，缺乏T细胞和B细胞，同时具备固有免疫缺陷，因此成为人类造血干细胞和人类实体瘤移植的受体。

Fig1. Body weight growth curve of NOD SCID (n=168)

Fig 2. Detection of serum antibody subclasses in NOD SCID mice (8-week old, male).

Fig3. Complete deletion of T, B and NK cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of T, B and NK cells by FACS.

Fig4. Complete deletion of Monocytes, macrophages and DC cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of Monocytes, macrophages and DC cells by FACS.

Fig5. Pathological examination of various tissues in NOD SCID mice. Thymus was absent in NOD SCID mice, and no significant pathologic abnormalities were found in the other tissues examined (8-week old, A males, B females).

Fig6. Subcutaneous xenograft tumor growth in NOD SCID. 

Fig7. Blood routine tests in NOD SCID.

Fig8. Blood biochemistry in NOD SCID.

Table 1. NOD SCID xenograft cell lines